Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor.

  title={Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor.},
  author={Yin Chen and Martin J. Cann and Tatiana N Litvin and Vadim Iourgenko and Meeghan L Sinclair and Lonny R. Levin and Jochen Buck},
  volume={289 5479},
Spermatozoa undergo a poorly understood activation process induced by bicarbonate and mediated by cyclic adenosine 3',5'-monophosphate (cAMP). It has been assumed that bicarbonate mediates its effects through changes in intracellular pH or membrane potential; however, we demonstrate here that bicarbonate directly stimulates mammalian soluble adenylyl cyclase (sAC) activity in vivo and in vitro in a pH-independent manner. sAC is most similar to adenylyl cyclases from cyanobacteria, and… CONTINUE READING
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