Soluble adenylyl cyclase activity is necessary for retinal ganglion cell survival and axon growth.

Abstract

cAMP is a critical second messenger mediating activity-dependent neuronal survival and neurite growth. We investigated the expression and function of the soluble adenylyl cyclase (sAC, ADCY10) in CNS retinal ganglion cells (RGCs). We found sAC protein expressed in multiple RGC compartments including the nucleus, cytoplasm and axons. sAC activation increased… (More)
DOI: 10.1523/JNEUROSCI.5288-11.2012

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@article{Corredor2012SolubleAC, title={Soluble adenylyl cyclase activity is necessary for retinal ganglion cell survival and axon growth.}, author={Raul G. Corredor and Ephraim F. Trakhtenberg and Wolfgang Pita-Thomas and Xiaolu Jin and Ying Hu and Jeffrey L. Goldberg}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2012}, volume={32 22}, pages={7734-44} }