Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization.

  title={Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization.},
  author={Fang Xie and Manuel Aguado Garc{\'i}a and Anne E Carlson and Sonya M Schuh and Donner F. Babcock and B. Shruti Jaiswal and Jan A. Gossen and Gloria Esposito and Marcel van Duin and M. P{\'e}rez-D{\'i}az Conti},
  journal={Developmental biology},
  volume={296 2},
We previously demonstrated that male mice deficient in the soluble adenylyl cyclase (sAC) are sterile and produce spermatozoa with deficits in progressive motility and are unable to fertilize zona-intact eggs. Here, analyses of sAC(-/-) spermatozoa provide additional insights into the functions linked to cAMP signaling. Adenylyl cyclase activity and cAMP content are greatly diminished in crude preparations of sAC(-/-) spermatozoa and are undetectable after sperm purification. HCO(3)(-) is… CONTINUE READING
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