Soluble adenylate cyclase reveals the significance of compartmentalized cAMP on endothelial cell barrier function.

@article{Sayner2006SolubleAC,
  title={Soluble adenylate cyclase reveals the significance of compartmentalized cAMP on endothelial cell barrier function.},
  author={Sarah L. Sayner and Troy Stevens},
  journal={Biochemical Society transactions},
  year={2006},
  volume={34 Pt 4},
  pages={492-4}
}
Within pulmonary microvascular endothelial cells, activation of endogenous adenylate cyclase generates tightly regulated cAMP transitions in the subplasma membrane space. These cAMP fluxes strengthen contacts between adjacent cells to tighten their barrier function. However, pathogenic bacteria have devised a mechanism to transfer toxic adenylate cyclases into eukaryotic cells and generate a cytosolic pool of cAMP that disrupts the barrier. To determine whether membrane or cytosolic cAMP… CONTINUE READING
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