Soluble Tumor Necrosis Factor-α (TNF-α) Receptors in Human Colostrum and Milk Bind to TNF-α and Neutralize TNF-α Bioactivity

@article{Buescher1998SolubleTN,
  title={Soluble Tumor Necrosis Factor-α (TNF-α) Receptors in Human Colostrum and Milk Bind to TNF-α and Neutralize TNF-α Bioactivity},
  author={E. Stephen Buescher and Penney McWilliams-Koeppen},
  journal={Pediatric Research},
  year={1998},
  volume={44},
  pages={37-42}
}
We used column chromatography, affinity binding, and bioassay methods to address whether the soluble tumor necrosis factor (TNF)-α receptors present in human colostrum and milk bind to and modify TNF-α bioactivity. In gel chromatography experiments, soluble TNF-α receptor I (sTNFRI) and sTNFRII in human colostrum sequentially increased their molecular sizes… CONTINUE READING