Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis.

@article{Cassatella2007SolubleTC,
  title={Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis.},
  author={Marco A Cassatella and Gabriela Pereira-da-Silva and Ilaria Tinazzi and Fabio F. Facchetti and Patrizia Scapini and Federica Calzetti and Nicola Tamassia and Ping Wei and Bernardetta Nardelli and Viktor V. Roschke and Annunciata Vecchi and Alberto Mantovani and Lisa Maria Bambara and S W Edwards and Antonio Carletto},
  journal={Journal of immunology},
  year={2007},
  volume={178 11},
  pages={7325-33}
}
TNF-like cytokine (TL1A) is a newly identified member of the TNF superfamily of ligands that is important for T cell costimulation and Th1 polarization. However, despite increasing information about its functions, very little is known about expression of TL1A in normal or pathological states. In this study, we report that mononuclear phagocytes appear to be a major source of TL1A in rheumatoid arthritis (RA), as revealed by their strong TL1A expression in either synovial fluids or synovial… CONTINUE READING

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