Soluble Nogo-66 receptor prevents synaptic dysfunction and rescues retinal ganglion cell loss in chronic glaucoma.

@article{Fu2011SolubleNR,
  title={Soluble Nogo-66 receptor prevents synaptic dysfunction and rescues retinal ganglion cell loss in chronic glaucoma.},
  author={Qing-ling Fu and Xin-Xue Liao and Xin Li and Dong Chen and Jianbo Shi and Weiping Wen and Daniel H. S. Lee and Kwok-fai So},
  journal={Investigative ophthalmology \& visual science},
  year={2011},
  volume={52 11},
  pages={
          8374-80
        }
}
  • Q. Fu, Xin-Xue Liao, K. So
  • Published 1 October 2011
  • Biology, Medicine
  • Investigative ophthalmology & visual science
PURPOSE Myelin inhibitory proteins inhibit axon growth and synaptic function by binding to the Nogo-66 receptor (NgR)1 in the central nervous system. Glaucoma is a progressive neuropathy characterized by loss of vision as a result of retinal ganglion cell (RGC) death. Synaptic degeneration is thought to be an early pathology of neurodegeneration in glaucoma and precedes RGC loss. The authors aimed to examine whether the NgR1 antagonist promotes synaptic recovery and RGC survival in glaucoma… 

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