Soluble JAGGED1 inhibits pulmonary hypertension by attenuating notch signaling.

  title={Soluble JAGGED1 inhibits pulmonary hypertension by attenuating notch signaling.},
  author={Yongguang Xiao and Dan Gong and Wei Wang},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={33 12},
OBJECTIVE Notch signaling has been implicated in the development of pulmonary arterial hypertension (PH) as reflected by increased expression of Notch member proteins that induce the proliferation of pulmonary arterial smooth muscle cells (PASMCs). Soluble Jagged1 (sJag1) has been shown to inhibit Notch signaling in vitro and in vivo; however, its capacity to suppress PH remains unknown. APPROACH AND RESULTS Notch1, Notch3, Jagged1, and Herp2 protein were highly expressed in both the mouse… CONTINUE READING


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