Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15.

@article{Bulanova2007SolubleII,
  title={Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15.},
  author={Elena Bulanova and Vadim Budagian and Erwin H. Duitman and Zane Orinska and Hans Krause and Ren{\'e} R{\"u}ckert and Norbert Reiling and S Bulfone-Paus},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 18},
  pages={
          13167-79
        }
}
Interleukin 15 (IL-15) is a pleiotropic cytokine that is hardly detectable in biological fluids. Here, we show that IL-15 forms functional heterocomplexes with soluble high affinity IL-15 receptor alpha (IL-15Ralpha) chain in mouse serum and cell-conditioned medium, which prevents IL-15 detection by ELISA. We also demonstrate that two soluble IL-15Ralpha (sIL-15Ralpha) sushi domain isoforms are generated through a novel alternative splicing mechanism within the IL-15Ralpha gene. These isoforms… CONTINUE READING

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