Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology.

@article{Ruchatz1998SolubleIR,
  title={Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology.},
  author={Holger Ruchatz and Bernard Pui Lam Leung and X Q Wei and Iain B. Mcinnes and Foo Yew Eddy Liew},
  journal={Journal of immunology},
  year={1998},
  volume={160 11},
  pages={5654-60}
}
IL-15 has recently been detected in the synovium of patients with rheumatoid arthritis. IL-15-activated T cells induce significant TNF-alpha synthesis by macrophages via a cell contact-dependent mechanism, suggesting a key regulatory role for IL-15. Here, we report that the administration of a soluble fragment of IL-15Ralpha into DBA/1 mice, profoundly suppressed the development of collagen-induced arthritis. This was accompanied in vitro by marked reductions in Ag-specific proliferation and… CONTINUE READING
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