Soluble HLA-G: Are they clinically relevant?

  title={Soluble HLA-G: Are they clinically relevant?},
  author={Vito Pistoia and Fabio Morandi and Xinhui Wang and Soldano Ferrone},
  journal={Seminars in cancer biology},
  volume={17 6},
HLA-G is a non-classical HLA-class Ib molecule with multiple immunoregulatory properties. Its main function in physiological conditions is to abrogate maternal NK cell activity against foetal tissue and to establish immune tolerance at maternal-foetal interface. HLA-G is expressed not only as a membrane bound molecule on the surface of cells, but also as a soluble moiety in body fluids. The major isoforms of HLA-G present in serum are soluble HLA-G1 and HLA-G5 which are generated by shedding or… CONTINUE READING
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