Soluble FLT-1 is detectable in the sera of colorectal and breast cancer patients.

@article{Kumar2002SolubleFI,
  title={Soluble FLT-1 is detectable in the sera of colorectal and breast cancer patients.},
  author={Harish Kumar and Kamal Heer and John Greenman and Michael John Kerin and John R. T. Monson},
  journal={Anticancer research},
  year={2002},
  volume={22 3},
  pages={1877-80}
}
BACKGROUND VEGF is the key factor in angiogenesis which is essential for the development and progression of solid tumours. VEGF acts via two high affinity receptors: KDR and FLT-1. FLT-1 exists both in membrane-fixed and soluble forms. The soluble form is perhaps the only known natural direct antagonist of VEGF and may have a role in anti-angiogenesis therapy. MATERIALS AND METHODS We developed an in-house ELISA and have assayed soluble FLT-1 in the sera of cancer patients. We assayed… CONTINUE READING

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