Soluble DPP4 induces inflammation and proliferation of human smooth muscle cells via protease-activated receptor 2.

@article{Wronkowitz2014SolubleDI,
  title={Soluble DPP4 induces inflammation and proliferation of human smooth muscle cells via protease-activated receptor 2.},
  author={Nina Wronkowitz and Sven Wolfgang G{\"o}rgens and Tania Romacho and Laura A. Villalobos and Carlos F{\'e}lix S{\'a}nchez-Ferrer and Concepci{\'o}n Peir{\'o} and Henrike Sell and J{\"u}rgen Eckel},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1842 9},
  pages={1613-21}
}
DPP4 is an ubiquitously expressed cell-surface protease that is shedded to the circulation as soluble DPP4 (sDPP4). We recently identified sDPP4 as a novel adipokine potentially linking obesity to the metabolic syndrome. The aim of this study was to investigate direct effects of sDPP4 on human vascular smooth muscle cells (hVSMCs) and to identify responsible signaling pathways. Using physiological concentrations of sDPP4, we could observe a concentration-dependent activation of ERK1/2 (3-fold… CONTINUE READING