Soluble CD27 induces IgG production through activation of antigen-primed B cells.

@article{Dang2012SolubleCI,
  title={Soluble CD27 induces IgG production through activation of antigen-primed B cells.},
  author={Linh Vu Phuong Dang and Anna Nilsson and Hanna M Ingelman-Sundberg and Alberto Cagigi and Luc B. S. Gelinck and Kehmia Titanji and Angelo de Milito and Sven Grutzmeier and Jacquelyn A. Hedlund and Frank P. Kroon and F Chiodi},
  journal={Journal of internal medicine},
  year={2012},
  volume={271 3},
  pages={282-93}
}
OBJECTIVES High levels of soluble CD27 (sCD27), a marker of immune activation, are found in several infectious [including human immunodeficiency virus type-I (HIV-1)] and autoimmune diseases; however, a direct biological effect of sCD27 on B cells has not been established. The aim of this study was to investigate whether sCD27, by binding to CD70, can induce immunoglobulin G (IgG) production from B cells. METHODS B cells from healthy and HIV-1-infected individuals were cultured with… CONTINUE READING

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High levels of soluble CD27 ( sCD27 ) , a marker of immune activation , are found in several infectious [ including human immunodeficiency virus type - I ( HIV-1 ) ] and autoimmune diseases ; however , a direct biological effect of sCD27 on B cells has not been established .
High levels of soluble CD27 ( sCD27 ) , a marker of immune activation , are found in several infectious [ including human immunodeficiency virus type - I ( HIV-1 ) ] and autoimmune diseases ; however , a direct biological effect of sCD27 on B cells has not been established .
High levels of soluble CD27 ( sCD27 ) , a marker of immune activation , are found in several infectious [ including human immunodeficiency virus type - I ( HIV-1 ) ] and autoimmune diseases ; however , a direct biological effect of sCD27 on B cells has not been established .
High levels of soluble CD27 ( sCD27 ) , a marker of immune activation , are found in several infectious [ including human immunodeficiency virus type - I ( HIV-1 ) ] and autoimmune diseases ; however , a direct biological effect of sCD27 on B cells has not been established .
High levels of soluble CD27 ( sCD27 ) , a marker of immune activation , are found in several infectious [ including human immunodeficiency virus type - I ( HIV-1 ) ] and autoimmune diseases ; however , a direct biological effect of sCD27 on B cells has not been established .
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