Soluble CD146 in cerebrospinal fluid of active multiple sclerosis.

  title={Soluble CD146 in cerebrospinal fluid of active multiple sclerosis.},
  author={Hongxia Duan and Yu Luo and Huifeng Hao and Liang Feng and Yanyan Zhang and D Lu and Shu Xing and Jing Feng and Dan Yang and L Song and Xiaojuan Yan},
The soluble form of CD146 has been reported to be present in various inflammatory diseases and displays pro-inflammatory properties. However, little is known about sCD146 in multiple sclerosis (MS). Here we show that sCD146 is significantly elevated in the cerebrospinal fluid of patients with active MS compared with that of inactive MS or patients with non-demyelinating diseases. Moreover, abnormally increased sCD146 in the CSF of active MS patients correlated with albumin quotient, MBP… CONTINUE READING
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