Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo.

@article{Klyubin2004SolubleAA,
  title={Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo.},
  author={Igor Klyubin and Dominic M Walsh and William K. Cullen and Julia V. Fadeeva and Roger Anwyl and Dennis J Selkoe and Michael J. Rowan},
  journal={The European journal of neuroscience},
  year={2004},
  volume={19 10},
  pages={
          2839-46
        }
}
Mutations in the amyloid precursor protein that result in substitutions of glutamic acid at residue 22 of the amyloid beta protein (A beta) with glutamine (Q22, Dutch) or glycine (G22, Arctic) cause aggressive familial neurological diseases characterized by cerebrovascular haemorrhages or Alzheimer's-type dementia, respectively. The present study compared the ability of these peptides to block long-term potentiation (LTP) of glutamatergic transmission in the hippocampus in vivo. The effects of… CONTINUE READING
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