Soluble A b oligomer-induced synaptopathy : c-Jun N-terminal kinase ’ s role

@inproceedings{Sclip2013SolubleAB,
  title={Soluble A b oligomer-induced synaptopathy : c-Jun N-terminal kinase ’ s role},
  author={Alessandra Sclip and Andrea Arnaboldi and Isabella Colombo and Pietro Veglianese and Laura Colombo and Massimo Messa and Simona Mancini and Sara Cimini and Federica Morelli and Xanthi Antoniou and Egbert Welker and Mario Salmona and Tiziana Borsello},
  year={2013}
}
Dear Editor, Among the neurodegenerative diseases, Alzheimer disease (AD) is the most common and severe age-related dementia for which there is currently no available treatment. Many studies support the assumption that AD is a spine pathology (Selkoe, 2002; Sivanesan et al., 2013) and that soluble amyloid-b (Ab) oligomers are causative of AD synaptopathy. Diverse lines of evidence indicate that Aboligomers induce formation of pore-like structures on the membrane (Arispe et al., 1993; Lashuel et… CONTINUE READING