Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease.

@article{Zhang2011SolubleAL,
  title={Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease.},
  author={Wei Zhang and Jian Hao and Rui Liu and Zhuo Zhang and Gesheng Lei and Changjun Su and Jianting Miao and Zhuyi Li},
  journal={Behavioural brain research},
  year={2011},
  volume={222 2},
  pages={342-50}
}
Amyloid-beta peptide (Aβ) is believed to be central in the pathogenesis of Alzheimer's disease (AD) characterized by cognitive deficits. However, it remains uncertain which form(s) of Aβ pathology is responsible for the cognitive deficits in AD. In the present study, the cognitive deficits and the profiles of Aβ pathology were characterized in the 12-month-old APPswe/PS1dE9 double transgenic mice, and their correlations were examined. Compared with non-transgenic littermates, the middle-aged… CONTINUE READING

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