Solubilized formulation of olmesartan medoxomil for enhancing oral bioavailability.

  title={Solubilized formulation of olmesartan medoxomil for enhancing oral bioavailability.},
  author={Bong Sang Lee and Myung Kang and Woo Sik Choi and Yoon Bae Choi and Hyung Soo Kim and Sang Kil Lee and Jaehwi Lee and Young Wook Choi},
  journal={Archives of pharmacal research},
  volume={32 11},
Olmesartan medoxomil (OLM) is an antihypertensive angiotensin II receptor blocker. OLM has a low bioavailability (BA), approximately 26% in humans, due to its low water solubility and efflux by drug resistance pumps in the gastrointestinal tract. Self-microemulsifying drug delivery system (SMEDDS), which is easily emulsified in aqueous media under gentle agitation and digestive motility, was formulated to increase the oral BA of OLM. Among the surfactants and oils studied, Capryol 90, Tween 20… CONTINUE READING