Solubilization of simvastatin and phytosterols in a dilutable microemulsion system.

@article{Fisher2013SolubilizationOS,
  title={Solubilization of simvastatin and phytosterols in a dilutable microemulsion system.},
  author={Sarah Kate Fisher and E. J. Wachtel and Abraham Aserin and Nissim Garti},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2013},
  volume={107},
  pages={
          35-42
        }
}
The usual treatment of hypercholesterolemia includes a class of drugs known as statins (simvastatin among them), which inhibit the production of cholesterol. Another way of reducing cholesterol levels is with the use of phytosterols, which reduce the transport of exogenic cholesterol from the intestine into the blood stream. The two treatments can be combined, achieving an additive effect. However, both simvastatin and phytosterols are practically insoluble in water, and therefore their… CONTINUE READING