Solubilization of menthol by platycodin D in aqueous solution: an integrated study of classical experiments and dissipative particle dynamics simulation.

@article{Ding2015SolubilizationOM,
  title={Solubilization of menthol by platycodin D in aqueous solution: an integrated study of classical experiments and dissipative particle dynamics simulation.},
  author={Haiou Ding and Qianqian Yin and Guang Wan and Xingxing Dai and Xinyuan Shi and Yanjiang Qiao},
  journal={International journal of pharmaceutics},
  year={2015},
  volume={480 1-2},
  pages={
          143-51
        }
}
Menthol (M) and platycodin D (PD) are the main active ingredients in Mentha haplocalyx and Platycodon grandiflorum A. DC., respectively. They are commonly used in combination in traditional Chinese medicine. In this study, laboratory experiments and computer simulations were used to investigate the solubilization of M by PD, which was believed to be one of the main causes of the synergistic effect of M. haplocalyx and P. grandiflorum A. DC. Results showed that both the method by which M was… 
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References

SHOWING 1-10 OF 36 REFERENCES
A Mesoscopic Simulation Study on the Solubilization of Menthol by Platycodin D
Mesodyn simulation is employed in this research to investigate the influences of temperature on the solubilization of menthol by platycodin D. The results show that the crucial factor on the speed of
Structure-function relationship of the saponins from the roots of Platycodon grandiflorum for hemolytic and adjuvant activity.
TLDR
Interestingly, the hemolytic and adjuvant activities of PD, PD2, PA, and PGD significantly not only promoted concanavalin A (Con A)-, lipopolysaccharide (LPS)- and antigen-induced splenocyte proliferation, but enhanced the NK cell activity in mice immunized with rL-H5.
Solubilizing Properties of Glycyrrhizin and Its Derivatives : Solubilization of Saikosaponin-a, the Saponin of Bupleuri Radix
Licorice root is often co-prescribed with Bupleuri Radix (Bupleurum root) for decoctions used in oriental traditional medicine. It was found that the water solubility of saikosaponin-a, the active
Influence of phytogenic surfactants (quillaya saponin and soya lecithin) on bio-elimination of phenanthrene and fluoranthene by three bacteria
TLDR
The results suggest that some phytogenic surfactants might improve PAH bioavailability in rhizospheres.
Molecular and mesoscopic study of ionic liquids and their use as solvents of active agents released by polymeric vehicles
This work explores the diffusivity of the drug albendazole contained in a polymeric vehicle, Styrene-Divinylbenzene (ST-DVD), when it is subject to different environments. The environments consist of
SOLUBILIZATION OF POLYCYCLIC AROMATIC HYDROCARBONS IN MICELLAR NONIONIC SURFACTANT SOLUTIONS
Experimental data are presented on the enhanced apparent solubilities of naphthalene, phenanthrene, and pyrene resulting from solubilization in aqueous solutions of four commercial, nonionic
Effects of saponins on the water solubility of different model compounds.
TLDR
Saponins generally should not be regarded as solubilizers because of the weak influence they have on aqueous solubility.
[Advances in studies on Platycodon grandiflorum].
TLDR
This paper has mainly reviewed the progress of P. grandiflorum on the processing in planting area, chemical constituents, quality standard, pharmacological effects and clinical application in recent ten years, which has provided the important references for its further study, exploitation and application.
Effect of composition on the formation of poly(dl-lactide) microspheres for drug delivery systems: Mesoscale simulations
In this work, the structure–property relationship of drug delivery systems (DDS) is investigated by dissipative particle dynamics (DPD) simulations. Nifedipine is selected as the model drug, whereas
Evaluation of biosurfactants for crude oil contaminated soil washing.
TLDR
These studies suggest that knowledge of surfactants' behaviour across different systems is paramount before their use in the practical application of oil removal, due to the low crude oil solubilization of 0.11%.
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