Solubilization and stabilization of carotenoids using micelles: Delivery of lycopene to cells in culture

@article{Xu1999SolubilizationAS,
  title={Solubilization and stabilization of carotenoids using micelles: Delivery of lycopene to cells in culture},
  author={Xiaoying Xu and Yan Wang and Andreas I. Constantinou and Maria Stacewicz-Sapuntzakis and Phyllis E. Bowen and Richard B. van Breemen},
  journal={Lipids},
  year={1999},
  volume={34},
  pages={1031-1036}
}
The use of the organic cosolvents tetrahydrofuran and dimethylsulfoxide was found to be unsuitable for prostate tunor cell cultures because of solvent cytotoxicity and the poor solubility and instability of lycopene. For example, the half-life of lycopene in organic/aqueous solution was found to be less than 2 h. Therefore, a micellar preparation of lycopene was developed for the solubilization and stabilization of lycopene in cell culture media. Neither the micelles themselves nor lycopene… CONTINUE READING
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