• DOI:10.1016/s0021-9258(19)41847-4
Corpus ID: 2337848

Solubilization and partial characterization of rat liver squalene epoxidase.

@article{Ono1975SolubilizationAP,
  title={Solubilization and partial characterization of rat liver squalene epoxidase.},
  author={T. Ono and K. Bloch},
  journal={The Journal of biological chemistry},
  year={1975},
  volume={250 4},
  pages={
          1571-9
        }
}

T. Ono, K. Bloch

Published 1975

Chemistry, Medicine

The Journal of biological chemistry

The microsomal enzyme system from rat liver which catalyzes squalene epoxidation requires a supernatant protein and phospholipids (Tai, H., and Bloch, K. (1972) J. Biol. Chem. 247, 3767). It has now been found that these two cytoplasmic components can be replaced by Triton X-100. The same detergent solubilizes the microsomal squalene epoxidase and the resulting supernatant can be separated into two components, A and B, by DEAE-cellulose chromatography. Neither Fraction A nor B alone has… CONTINUE READING

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