Solubilization, partial purification and functional reconstitution of a sheep brain endoplasmic reticulum anion channel.


1. An intracellular anion channel, known to be co-localized in brain endoplasmic reticulum membranes with ryanodine-sensitive calcium-release channels, was incorporated into voltage-clamped planar lipid bilayers from sheep brain microsomal membrane vesicles. 2. Single channels, which displayed a main open-state conductance of 80-100 pS in symmetric 450 mM… (More)


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