Solubility of calcium soaps of long-chain fatty acids in simulated intestinal environment

@article{Graham2005SolubilityOC,
  title={Solubility of calcium soaps of long-chain fatty acids in simulated intestinal environment},
  author={David Yates Graham and Jeffrey W. Sackman},
  journal={Digestive Diseases and Sciences},
  year={2005},
  volume={28},
  pages={733-736}
}
Calcium soaps of long-chain fatty acids are often referred to as being insoluble. These soaps make up most of the fecal lipid in infants fed high calcium diets and are responsible for increased fat malabsorption in patients with exocrine pancreatic insufficiency receiving enzymes and calcium carbonate antacids. We investigated the solubility of the calcium soaps of long-chain fatty acids in simulated human intestinal contents. Calcium soaps of the [14C]fatty acids of lauric (12∶0), palmitic (16… 
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29 Citations

Fatty Acids from Different Fat Sources and Dietary Calcium Concentration Differentially Affect Fecal Soap Formation in Growing Pigs.

TLDR
Ca-fatty acid soap formation led to decreased fat absorption in the GIT of growing pigs, which supports the hypothesis that higher dietary Ca concentrations reduce fat absorption.

Development of an Assay to Determine the Amount of Ca-Fatty Acid Soaps in Feces.

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The method is suitable for determining fatty acids in the form of Ca-fatty acid soaps in feces and shows consistent and high recovery of fatty acid-soaps.

Effect of excess dietary calcium on colon mucosal membranes and fecal lipids

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Results indicate that excess dietary calcium resulted in alteration in the density of 4 protein bands of colon apical membranes upon examination on SDS-gel electrophoresis, which may be due to either the reduction of fecal water bile acids and free fatty acids or a direct effect of dietary calcium on membrane proteins.

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It is suggested that cheese is an effective matrix for the controlled release of nutrients and for the protection of green tea polyphenol integrity and biological activity in the gastrointestinal environment.

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Both micellarization and uptake were significantly inhibited by minerals in a concentration-dependent manner, with stronger effects for Fe and Zn compared to Ca and Mg.

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