Solubility enhancement of celecoxib using beta-cyclodextrin inclusion complexes.

@article{Rawat2004SolubilityEO,
  title={Solubility enhancement of celecoxib using beta-cyclodextrin inclusion complexes.},
  author={Swati Rawat and Sanjay K Jain},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2004},
  volume={57 2},
  pages={263-7}
}
Celecoxib has very low water solubility. It forms a complex with beta-cyclodextrin (betaCD) both in aqueous and in solid state. It was observed that due to formation of the inclusion complex, the solubility and dissolution rate of celecoxib were enhanced. The formation of 1:1 complex with betaCD in solution was confirmed by phase solubility and spectral shift studies. The apparent stability constants calculated by these techniques were 881.5 and 341.5 M(-1), respectively. The solid inclusion… CONTINUE READING

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