Solubility and dissolution rate enhancement of lumefantrine using hot melt extrusion technology with physicochemical characterisation

@article{Fule2013SolubilityAD,
  title={Solubility and dissolution rate enhancement of lumefantrine using hot melt extrusion technology with physicochemical characterisation},
  author={Ritesh Fule and Tariq Meer and Ajay Kumar Sav and Purnima Dhanraj Amin},
  journal={Journal of Pharmaceutical Investigation},
  year={2013},
  volume={43},
  pages={305-321}
}
The interest in hot-melt extrusion as a drug delivery technology for the production of solid dispersion is growing rapidly. Lumefantrine (LUMF) is an antimalarial drug that exhibits poor oral bioavailability, in consequence of its poor aqueous solubility. To improve its antimalarial activity, solid dispersion formulation using hot melt extrusion technology was prepared. Appropriate selection of polymers, favoured the production of amorphous LUMF-polymer solid dispersions. The physicochemical… CONTINUE READING
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