Solubility and bioavailability improvement of pazopanib hydrochloride.

Abstract

The anti-cancer drug pazopanib hydrochloride (PZH) has a very low aqueous solubility and a variable oral bioavailability. A new pharmaceutical formulation with an improved solubility may enhance the bioavailability and reduce the variability. A broad selection of polymer excipients was tested for their compatibility and solubilizing properties by… (More)
DOI: 10.1016/j.ijpharm.2018.04.037

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