Solubilities and intrinsic dissolution rates of sulphamethoxazole and trimethoprim.

@article{Dahlan1987SolubilitiesAI,
  title={Solubilities and intrinsic dissolution rates of sulphamethoxazole and trimethoprim.},
  author={R Dahlan and Cari McDonald and Vivian Bruce Sunderland},
  journal={The Journal of pharmacy and pharmacology},
  year={1987},
  volume={39 4},
  pages={246-51}
}
The influence of pH on the dissolution rates and solubilities of sulphamethoxazole and trimethoprim have been examined. Sulphamethoxazole was evaluated in buffers of ionic strength 0.5 mol dm-3 over the pH range 0.45-7.8 and at 25, 32 and 37 degrees C. The minimum solubility of sulphamethoxazole was 28.1 mg/100 mL at pH 3.22 and 25 degrees C. Solubilities increased significantly with both increased and decreased pH. Intrinsic dissolution rates demonstrated a linear relationship with the… CONTINUE READING