Solitary sclerosis
@article{Schmalstieg2012SolitaryS, title={Solitary sclerosis}, author={William F. Schmalstieg and B. Mark Keegan and Brian G. Weinshenker}, journal={Neurology}, year={2012}, volume={78}, pages={540 - 544} }
Objective: To present a case series of patients with progressive myelopathy in the setting of a solitary demyelinating lesion. Methods: We describe 7 patients evaluated over a 6-year period. All had progressive motor impairment attributable to an MRI lesion compatible with a demyelinating plaque in the brainstem or upper cervical spinal cord. At the time of evaluation, none met the International Panel imaging criteria for dissemination in space, and none described clinical symptoms consistent…
37 Citations
Prognostic value of spinal cord MRI in multiple sclerosis patients.
- Medicine, PsychologyRevue neurologique
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Long-term outcome in multiple sclerosis patients treated with fingolimod.
- Medicine, PsychologyMultiple sclerosis and related disorders
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Onset of progressive motor impairment in patients with critical central nervous system demyelinating lesions
- Medicine, PsychologyMultiple sclerosis
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The “critical” demyelinating lesion rather than total brain MRI lesion burden is the major contributor to motor-progression onset in these cohorts with highly restricted versus unlimited magnetic resonance imaging (MRI) lesionurden.
Cerebral hemodynamics in patients with multiple sclerosis.
- Medicine, PsychologyMultiple sclerosis and related disorders
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Critical spinal cord lesions associate with secondary progressive motor impairment in long-standing MS: A population-based case-control study
- Medicine, PsychologyMultiple sclerosis
- 2020
Investigating whether similar spinal cord lesions are more frequent in long-standing MS patients with secondary progressive motor impairment versus those maintaining a relapsing-remitting course found only the presence of potential critical lesions independently associated with motor progression was linked to motor progression.
Progressive Multifocal Myelopathy or Multiple Sclerosis?
- MedicineMultiple sclerosis and related disorders
- 2020
Unilateral motor progression in MS
- Psychology, MedicineNeurology
- 2019
In patients with MS with unilateral motor progression, the motor deficit may be attributable to a single critical corticospinal tract lesion.
Phases and Phenotypes of Multiple Sclerosis.
- Medicine, PsychologyContinuum
- 2019
It is suggested that interventions to prevent progressive MS, when they become available for clinical practice, may need to be considered as early as when the asymptomatic radiologically isolated syndrome is detected.
Long term effects of corticosteroids in multiple sclerosis in terms of the “no evidence of disease activity” (NEDA) domains
- Medicine, PsychologySteroids
- 2019
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