Solitary sclerosis: progressive myelopathy from solitary demyelinating lesion. A new entity?

@article{Ayrignac2013SolitarySP,
  title={Solitary sclerosis: progressive myelopathy from solitary demyelinating lesion. A new entity?},
  author={Xavier Ayrignac and Clarisse Carra-Dalli{\`e}re and Pascale Homeyer and Pierre Labauge},
  journal={Acta Neurologica Belgica},
  year={2013},
  volume={113},
  pages={533-534}
}
Primary and secondary progressive multiple sclerosis (MS) results in an increasing neurologic deficit. In the context of steady progression of neurologic disability, cerebral and spinal cord MRI usually allow the diagnosis when they show evidence of dissemination in space [1]. Recently, Schmalstieg et al. [2] described 7 patients with progressive myelopathy related to a solitary demyelinating lesion within the brainstem or upper cervical spinal cord. 
Progressive solitary sclerosis: isolated lesion, progressive deficits Esclerose solitária progressiva: lesão única, défices progressivos
TLDR
A woman presented with an isolated intrinsic cord lesion which led to a progressive left lower limb motor deficit, illustrating a clinic-radiological paradox, and its etiology is still unknown.
Pattern Recognition of the Multiple Sclerosis Syndrome
TLDR
Clinicians’ awareness of the clinical nuances of the autoimmune conditions for MS and NMSOD are increased, and highly suggestive patterns of clinical, paraclinical or imaging presentations are highlighted in order to improve differentiation.
Vitamin K cream reduces reactions at the injection site in patients with relapsing–remitting multiple sclerosis treated with subcutaneous interferon beta – VIKING study
TLDR
Topical vitamin K seems to be useful to prevent, or at least to reduce, the development of burning sensations in patients with multiple sclerosis.
A Case Report of Solitary Sclerosis: This is Really Multiple Sclerosis
TLDR
The case of a 40-year-old patient treated for more than 2 years with high doses of biotin (CERENDAY®) for progressive symptoms of solitary sclerosis, who presented asymptomatic new T2 white matter lesions on brain magnetic resonance imaging (MRI).
Solitary sclerosis: Experience from three French tertiary care centres
TLDR
In all cases, the paraclinical investigations exclu-ded all potential differential diagnoses and Neuro-myelitis optica antibodies were negative for all patients.
Solitary sclerosis: Progressive neurological deficit from a spatially isolated demyelinating lesion: A further report
TLDR
Clinicians should be aware of such a diagnosis, to avoid invasive and often harmful tests particularly biopsies, and aware of the risks of misdiagnosing solitary demyelinating lesions.

References

SHOWING 1-3 OF 3 REFERENCES
Solitary sclerosis
TLDR
Deyelinating disease should be in the differential diagnosis of progressive myelopathy despite absence of dissemination in space, and Solitary demyelinating lesions may produce a progressiveMyelopathy similar to primary progressive MS.
Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria
TLDR
These revisions simplify the McDonald Criteria, preserve their diagnostic sensitivity and specificity, address their applicability across populations, and may allow earlier diagnosis and more uniform and widespread use.
Fig. 1 MRI performed 5 years after the onset of the disease. It shows the ventral cervicomedullary hyperintensity on axial T2 (a), sagittal T2 (b), and sagittal FLAIR MRI (c)
  • Fig. 1 MRI performed 5 years after the onset of the disease. It shows the ventral cervicomedullary hyperintensity on axial T2 (a), sagittal T2 (b), and sagittal FLAIR MRI (c)