Solitary median maxillary central incisor syndrome: clinical case with a novel mutation of sonic hedgehog.

@article{Garavelli2004SolitaryMM,
  title={Solitary median maxillary central incisor syndrome: clinical case with a novel mutation of sonic hedgehog.},
  author={Livia Garavelli and Claudio Zanacca and Gabriella Caselli and Giacomo Banchini and Christ{\'e}le Dubourg and Val{\'e}rie David and Sylvie Odent and Fiorella Gurrieri and Giovanni Neri},
  journal={American journal of medical genetics. Part A},
  year={2004},
  volume={127A 1},
  pages={93-5}
}
Solitary median maxillary central incisor (SMMCI) is a rare dental anomaly. It is usually considered as a minor manifestation of holoprosencephaly (HPE). Some reported families had severe cases of HPE in some members and SMMCI in others. Mutations of Sonic Hedgehog (SHH) have been documented in these families. SMMCI has also been found as an isolated finding or together with other anomalies such as microcephaly, short stature, endocrine pathology, and choanal atresia. We describe a patient with… CONTINUE READING