Solid-state variation of troglitazone drug substance by using a different recrystallization method.

@article{Suzuki2003SolidstateVO,
  title={Solid-state variation of troglitazone drug substance by using a different recrystallization method.},
  author={Nobuyuki Suzuki and Ko Kasahara and Yosikazu Watanabe and Suzue Kinoshita and Hirokazu Hasegawa and Tohru Kawasaki},
  journal={Drug development and industrial pharmacy},
  year={2003},
  volume={29 7},
  pages={
          805-12
        }
}
Rapid and slow crystallization methods (A and B) were applied for troglitazone, an equal mixture of four stereoisomers. Differences in the powder x-ray diffractometry patterns and hygroscopic patterns were observed among the samples crystallized by these methods, suggesting that troglitazone has solid-state variation. In this article, troglitazone recrystallized by method A was evaluated to clarify its structural characteristics and physical property. The crystal structure of predried… CONTINUE READING

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