Corpus ID: 36644428

Solid state conformations and antidopaminergic effects of remoxipride hydrochloride and a closely related salicylamide, FLA 797, in relation to dopamine receptor models.

@article{Hoegberg1986SolidSC,
  title={Solid state conformations and antidopaminergic effects of remoxipride hydrochloride and a closely related salicylamide, FLA 797, in relation to dopamine receptor models.},
  author={T. Hoegberg and S. Raemsby and T. de Paulis and B. Stensland and I. Cs{\"o}regh and A. W{\"a}gner},
  journal={Molecular pharmacology},
  year={1986},
  volume={30 4},
  pages={
          345-51
        }
}
  • T. Hoegberg, S. Raemsby, +3 authors A. Wägner
  • Published 1986
  • Chemistry, Medicine
  • Molecular pharmacology
  • The X-ray structures of two new 2,6-disubstituted benzamides, i.e., remoxipride hydrochloride monohydrate [-)-(S)-3-bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,6-dimethoxybenza mide hydrochloride monohydrate) and FLA 797 [-)-(S)-3-bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamide ), have been determined as well as the distribution coefficients. The difference in dopamine receptor blocking activity is discussed in terms of lipophilicity and solid state conformations of the two… CONTINUE READING
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