Solid state characterization of olanzapine polymorphs using vibrational spectroscopy.

@article{Ayala2006SolidSC,
  title={Solid state characterization of olanzapine polymorphs using vibrational spectroscopy.},
  author={Alejandro P Ayala and Heinz Wilhelm Siesler and R. B{\"o}se and G{\"u}nter G Hoffmann and Griselda I Polla and Daniel Roberto Vega},
  journal={International journal of pharmaceutics},
  year={2006},
  volume={326 1-2},
  pages={69-79}
}
FT-Raman, infrared and near infrared investigations of two polymorphs of olanzapine are presented, establishing the main features that allow the discrimination of these crystalline forms using vibrational spectroscopic methods. Ab initio calculations on the basis of the density functional theory were used to determine the stable conformations. The calculated vibrational spectra were compared to the experimental ones in order to identify the conformers corresponding to each polymorph and to… CONTINUE READING