Solid-state NMR reveals the hydrophobic-core location of poly(amidoamine) dendrimers in biomembranes.

@article{Smith2010SolidstateNR,
  title={Solid-state NMR reveals the hydrophobic-core location of poly(amidoamine) dendrimers in biomembranes.},
  author={Pieter E. S. Smith and Jeffrey R. Brender and Ulrich H. N. D{\"u}rr and Jiadi Xu and Douglas G. Mullen and Mark M Banaszak Holl and Ayyalusamy Ramamoorthy},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 23},
  pages={8087-97}
}
Poly(amidoamine) (PAMAM) dendrimer nanobiotechnology shows great promise in targeted drug delivery and gene therapy. Because of the involvement of cell membrane lipids with the pharmacological activity of dendrimer nanomedicines, the interactions between dendrimers and lipids are of particular relevance to the pharmaceutical applications of dendrimers. In this study, solid-state NMR was used to obtain a molecular image of the complex of generation-5 (G5) PAMAM dendrimer with the lipid bilayer… CONTINUE READING
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