Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions.

@article{Adebisi2016SolidstateTA,
  title={Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions.},
  author={Adeola O. Adebisi and Waseem Kaialy and Tariq Hussain and Hiba Al-Hamidi and Ali Nokhodchi and Barbara R. Conway and Kofi Asare-Addo},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2016},
  volume={146},
  pages={
          841-51
        }
}
This work explores the use of both spray drying and d-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging were also conducted. The results showed that the spray dried PXM alone, without GLU produced some PXM form II (DSC results) with no… Expand
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References

SHOWING 1-10 OF 80 REFERENCES
Triboelectrification and dissolution property enhancements of solid dispersions.
TLDR
The results show the selection of solvents can influence powder charge thereby improving powder handling as well as dissolution properties and the method of preparation of the dispersion induced polymorphic forms of the drug. Expand
Characterization of solid dispersions of rofecoxib using differential scanning calorimeter
SummarySolid dispersions were prepared to enhance the dissolution rate of rofecoxib. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used for the characterization of solidExpand
Preparation and characterization of microparticles of piroxicam by spray drying and spray chilling methods
TLDR
It was believed that spray drying of piroxicam is a useful tool to improve dissolution but not in case of spray chilling, but the dissolution of the spray dried microparticle and spray chilled particles were improved compared with recrystallized and pure sample of pIROxicAM. Expand
An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine
Abstract One of strategies adopted to improve the dissolution rates of poorly soluble drugs is by co-grinding the drug with a hydrophilic carrier. However, the introduction of mechanical forcesExpand
The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HCl
TLDR
Solid state analysis showed that ibuprofen is stable under grinding conditions, but the presence of high concentration of GL in samples subjected to high grinding times caused changes in FT-IR spectrum of Ibu, which could be due to intermolecular hydrogen bond or esterification between the carboxylic acid group in the ib uprofen and hydroxylgroup in the GL. Expand
Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine).
TLDR
The results showed that the dissolution rate of liquisolid tablets was not significantly affected by storing the tablets at 25 degrees C/75% relative humidity for a period of 6 months, and the results of DSC and X-ray crystallography did not show any changes in crystallinity of the drug and interaction between carbamazepine and exipients during the process. Expand
Preparation and characterization of fast dissolving flurbiprofen and esomeprazole solid dispersion using spray drying technique.
TLDR
The combined FLU and ESO SD powder can be effectively delivered as an immediate-release formulation using the macro-environmental pH modulation concept. Expand
Effect of glucosamine HCl on dissolution and solid state behaviours of piroxicam upon milling.
TLDR
Results showed that the presence of glucosamine HCl can increase dissolution rate of piroxicam compared to pure piroXicam, and this amino sugar has been shown to decrease pain and improve mobility in osteoarthritis in joints. Expand
Dissolution enhancement of the poorly soluble drug nifedipine by co-spray drying with microporous zeolite beta
Abstract Dissolution enhancement of nifedipine (NIF), a BSC class II drug, was achieved after co-spray drying with zeolite beta (BEA) in two drug to carrier ratios (1: 1, 1: 2). Extraction studiesExpand
To enhance dissolution rate of poorly water-soluble drugs: glucosamine hydrochloride as a potential carrier in solid dispersion formulations.
TLDR
It has been shown that the use of G-HCl in solid dispersion formulations can significantly enhance the dissolution rate of poorly water-soluble drugs such as carbamazepine. Expand
...
1
2
3
4
5
...