Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions.

  title={Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions.},
  author={Adeola O. Adebisi and Waseem Kaialy and Tariq Hussain and Hiba Al-Hamidi and Ali Nokhodchi and Barbara R. Conway and Kofi Asare-Addo},
  journal={Colloids and surfaces. B, Biointerfaces},
This work explores the use of both spray drying and d-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging were also conducted. The results showed that the spray dried PXM alone, without GLU produced some PXM form II (DSC results) with no… Expand
Freeze-dried crystalline dispersions: Solid-state, triboelectrification and simultaneous dissolution improvements
Abstract The charging propensities of freeze-dried samples produced from combinations of Piroxicam (PXM) - a BCS Class II drug with D-glucosamine HCl (GLU) - a potential hydrophilic carrier wereExpand
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  • 2019
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Formulation and optimization of quinoa starch nanoparticles: Quality by design approach for solubility enhancement of piroxicam
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To enhance dissolution rate of poorly water-soluble drugs: glucosamine hydrochloride as a potential carrier in solid dispersion formulations.
It has been shown that the use of G-HCl in solid dispersion formulations can significantly enhance the dissolution rate of poorly water-soluble drugs such as carbamazepine. Expand