Solid self-nanoemulsifying cyclosporin A pellets prepared by fluid-bed coating: preparation, characterization and in vitro redispersibility

@inproceedings{Lei2011SolidSC,
  title={Solid self-nanoemulsifying cyclosporin A pellets prepared by fluid-bed coating: preparation, characterization and in vitro redispersibility},
  author={Y. F. Lei and Yi Lu and Jianping Qi and Sufang Nie and Fuqiang Hu and Weisan Pan and Weiqiang Wu},
  booktitle={International journal of nanomedicine},
  year={2011}
}
BACKGROUND The objective of this study was to evaluate fluid-bed coating as a new technique to prepare a pellet-based solid self-nanoemulsifying drug delivery system (SNEDDS) using cyclosporin A as a model of a poorly water-soluble drug. METHODS The rationale of this technique was to entrap a Liquid SNEDDS in the matrix of the coating material, polyvinylpyrrolidone K30, by fluid-bed coating. Pseudoternary phase diagrams were used to screen the liquid SNEDDS formulations. The optimal… CONTINUE READING

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