Solid phase synthesis of the fibronectin glycopeptide V(Galβ3GalNAcα)THPGY, its β analogue, and the corresponding unglycosylated peptide


The fibronectin fragment VTHPGY and the corresponding glycopeptides V(Galβ3GalNAcα)THPGY and V(Galβ3GalNAcβ)THPGY were synthesized by the FMOC/solid phase approach. FMOC derivatives of threonine, carrying O-linked, peracetylated Galβ3GalNAc chains were used for introduction (HOBt-mediated coupling) of the disaccharide moieties. 
DOI: 10.1007/BF00769846