Solid-phase synthesis of pyridones and pyridopyrazines as peptidomimetic scaffolds.


[formula: see text] We report the syntheses of peptidomimetic opioids containing the core structure N-alkyl-2-alkyl-2,3-dihydro-4-pyridone. By employing imines bound on a solid support and the Danishefsky diene, this [4 + 2] cyclocondensation reaction facilitates the synthesis of novel complex heterocycles. The central reaction is carried out under mild… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.