Solid-phase synthesis of phenylalanine containing peptides using a traceless triazene linker.

@article{TorresGarca2012SolidphaseSO,
  title={Solid-phase synthesis of phenylalanine containing peptides using a traceless triazene linker.},
  author={Carolina Torres-Garc{\'i}a and Daniel Pulido and Magdalena Carceller and Iv{\'a}n Ramos and Miriam Royo and Ernesto Nicol{\'a}s},
  journal={The Journal of organic chemistry},
  year={2012},
  volume={77 21},
  pages={9852-8}
}
The use of a triazene function to anchor phenylalanine to a polymeric support through its side chain is reported. To prove the usefulness of this strategy in solid-phase peptide synthesis, several bioactive peptides have been prepared including cyclic, C-modified, and protected peptides. The triazene linkage is formed by coupling the diazonium salt of Fmoc-Phe(pNH(2))-OAllyl to a MBHA-polystyrene resin previously functionalized with isonipecotic acid (90%). Further assembly of the peptide chain… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS