• Corpus ID: 102753352

Solid phase synthesis of peptides and proteins

  title={Solid phase synthesis of peptides and proteins},
  author={Angus R. Brown},
A strategy for the total chemical synthesis and purification of proteins has been investigated and applied to the 85 residue methylated DNA binding domain (MBD) from the chromosomal protein MeCP2, the 66 residue Restriction Alleviation (Ral) protein from bacteriophage a, and the 76 residue ßchemokine Monocyte Chemotactic protein (MCP -1). The hydrophobicity of the Na protecting group tetrabenzo[ a, c ,g,i]fluorenyl17methoxyc)bonyl (Tbfmoc) has been exploited to simplify the rapid purification…