Solid phase synthesis of isariin, a long chain beta-hydroxy acid-containing cyclodepsipeptide, and its diastereoisomer.

@article{Okada1974SolidPS,
  title={Solid phase synthesis of isariin, a long chain beta-hydroxy acid-containing cyclodepsipeptide, and its diastereoisomer.},
  author={K. Okada and Y. Kurosawa and M. Hiramoto},
  journal={Chemical \& pharmaceutical bulletin},
  year={1974},
  volume={22 9},
  pages={
          2136-41
        }
}
The method of solid phase synthesis was applied to the preparation of isariin (Ia), a β-hydroxydodecanoic acid-containing cyclodepsipeptide metabolite of Isaria cretacea, and its isomer (Ib). The open-chain depsipeptide, H-Val-D-Leu-Ala-Val-DL-Hyd-Gly-OH, was synthesized by coupling successively BOC-Val-DL-Hyd-OH, alanine, and Z-Val-D-Leu-OH to resin-bound glycine using dicyclohexylcarbodiimide (DCC) or DCC+hydroxysuccinimide (HOSu) as coupling agent. After cleavage from the resin the… Expand
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