Solid phase synthesis of globomycin and SF-1902 A5.

  title={Solid phase synthesis of globomycin and SF-1902 A5.},
  author={Francisco Sarabia and Samy Chammaa and Cristina Garc{\'i}a-Ruiz},
  journal={The Journal of organic chemistry},
  volume={76 7},
The syntheses of the natural lipocyclodepsipeptide-type antibiotics globomycin and SF-1902 A(5) are reported, utilizing solid phase technology for the construction of the peptidic fragment and a new asymmetric methodology of epoxidation for the preparation of the lipidic chain. The linkage between both fragments was successfully achieved in solid phase to complete the syntheses via a macrolactonization reaction executed prior to the cleavage of the acyclic precursors from the solid support… 
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