Solid-phase synthesis of c(RGDfK) derivatives: on-resin cyclisation and lysine functionalisation.

@article{McCusker2002SolidphaseSO,
  title={Solid-phase synthesis of c(RGDfK) derivatives: on-resin cyclisation and lysine functionalisation.},
  author={Catherine F McCusker and Philip J Kocienski and Frederick Boyle and Andreas G. Sch{\"a}tzlein},
  journal={Bioorganic & medicinal chemistry letters},
  year={2002},
  volume={12 4},
  pages={547-9}
}
The cyclic pentapeptide c(RGDfK), a selective ligand for the alpha(v)beta3 integrin, was synthesised on solid phase. All synthetic operations including the cyclisation step and the appendage of the Bolton-Hunter reagent was conducted on-resin. 

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