Solid-phase synthesis of 16 potent (selective and nonselective) in vivo antagonists of oxytocin.

@article{Manning1989SolidphaseSO,
  title={Solid-phase synthesis of 16 potent (selective and nonselective) in vivo antagonists of oxytocin.},
  author={Maurice Manning and M. Kruszyński and Krzysztof Bańkowski and Aleksandra Olma and B. Lammek and Ling Ling Cheng and Wieslaw A Klis and Janny Seto and J Assist. - Surgeon NlTAl CHURN Haldar and Wilbur H. Sawyer},
  journal={Journal of medicinal chemistry},
  year={1989},
  volume={32 2},
  pages={382-91}
}
We describe the synthesis and some pharmacological properties of 16 new in vivo antagonists of oxytocin. These are based on modifications of three peptides: A, B, and C. A is our previously reported potent and selective antagonist of the vasopressor (V1 receptor) responses to arginine-vasopressin (AVP)/weak oxytocin antagonist, [1-(beta-mercapto-beta,beta-pentamethylenepropionic acid), 2-O-methyltyrosine]arginine-vasopressin (d(CH2)5[Tyr(Me)2]AVP. B reported here, the Ile3 analogue of A, is d… CONTINUE READING

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