Solid-phase synthesis and thermal denaturation study of cyclic PNAs targeting the HIV-1 TAR RNA loop.

Abstract

Cyclic PNAs targeting the HIV-1 TAR RNA loop have been synthesized following a convenient solid-phase strategy which allows on-resin cyclisation. UV-monitored thermal denaturation studies demonstrate that these cyclic PNAs are able to strongly interact with their TAR RNA target, very likely through the formation of a six-base pair stable complex, involving… (More)

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Cite this paper

@article{Upert2007SolidphaseSA, title={Solid-phase synthesis and thermal denaturation study of cyclic PNAs targeting the HIV-1 TAR RNA loop.}, author={Gr{\'e}gory Upert and Mohamed Nabil Mehiri and Audrey Di Giorgio and R. Condom and N Navarro Pati{\~n}o}, journal={Bioorganic & medicinal chemistry letters}, year={2007}, volume={17 21}, pages={6026-30} }