Solid phase synthesis and conformation of sequential glycosylated polytripeptide sequences related to antifreeze glycoproteins.

@article{Filira1990SolidPS,
  title={Solid phase synthesis and conformation of sequential glycosylated polytripeptide sequences related to antifreeze glycoproteins.},
  author={Fernando Filira and Laura Biondi and Barbara Scolaro and Maria Teresa Foffani and Stefano Mammi and Evaristo Peggion and Raniero Rocchi},
  journal={International journal of biological macromolecules},
  year={1990},
  volume={12 1},
  pages={
          41-9
        }
}
Sequential glycopeptides [Thr(beta-D-galactose)-Ala-Ala]n, with n ranging from 2 to 7, as models of natural antifreeze glycoproteins were synthesized by the continuous flow, solid phase procedure. The conformational properties of these materials in solution were investigated by c.d. and 1H-n.m.r. spectroscopy. In aqueous solution the c.d. pattern is practically independent of chain length and is very similar to that of natural antifreeze glycoproteins. The results are interpreted in terms of… Expand
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TLDR
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Natural abundance 13C NMR spectroscopy (at 67.9 MHz) is used to study an aqueous solution of the antifreeze glycoproteins 3 to 6 from the Antarctic cod. Assignments of resonances to specific carbonsExpand
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