Solid-phase staudinger ligation from a novel core-shell-type resin: a tool for facile condensation of small peptide fragments.

Abstract

[reaction: see text] Solid-phase Staudinger ligation of small peptides was performed on a novel core-shell-type resin. Solid-phase Staudinger ligation was mediated by synthetic solid-supported phosphinothiol, which was readily prepared by a straightforward synthetic route. This protocol afforded final peptide products in excellent yields and purities and… (More)

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