Solid-phase methylamidation for sialoglycomics by MALDI-MS.

  title={Solid-phase methylamidation for sialoglycomics by MALDI-MS.},
  author={Henghui Li and Xing Zhao and Qiwei Zhang and Xiaojun Feng and Bi-Feng Liu and Xin Liu},
  journal={Analytical and bioanalytical chemistry},
  volume={406 25},
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has been a major approach for glycan analysis. However, the preferential cleavage of the sialic acid moiety by in- and post-source decay influences the determination of sialylated glycans by MALDI-MS. Many chemical derivatization methods were introduced to stabilize the sialylated… CONTINUE READING